What we do

Simply put – we develop semi-permanent materials in lab that can be used in the body to heal damaged tissue and improve functionality.

What makes our materials unique is their ability to simultaneously provide structural support in wound beds while also behaving like a drug to promote healing. One of our most promising materials is a granular hydrogel called Microporous Annealed Particles (MAP). In fact, we dedicated a whole page to MAP Scaffolds because it’s such a rapidly growing technology.

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What motivates us

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STROKE-INDUCED DISABILITY

There are currently no treatments to restore brain function after stroke.

50 %

of stroke survivors are chronically disabled

POORLY HEALING WOUNDS

Wounds that can’t seem to heal are a major issue for compromised patients.

6.5 million

US patients suffer from chronic wounds

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NON-INVASIVE THERAPEUTICS

Treatments that require surgery introduce substantial risks that we want to bypass.

33.8 million

surgical operations in the US in 2010

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SCARLESS HEALING

Unlike tissue repair – where the body forms a scar – we aim for tissue regeneration.

$ 17.94

billion global scar treatment market

What inspires us

The body usually does an incredible job at healing itself. But what exactly do we mean by healing?

When tissue gets damaged, its overall function gets compromised. And since every tissue has an important job, the body tries to fix the situation as quickly as possible. But the quality of the fix can vary dramatically and sadly never reaches 100% in adults. This is because the normal healing process works toward tissue repair, where the body forms a scar to ‘patch-up’ the defect and get on with its life. However, with the right support system, scientists believe tissue regeneration is possible, where the body heals itself back to perfect working order.

We draw inspiration from the cellular mechanisms at play during natural wound healing to design our biomaterials. Read more

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How we do it

In general, these are our 3 main strategies (depending on the wound):

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Tweak the immune system

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Extend the window for cellular change

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Re-open the window for cellular change

But this is how we make our material:

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Start with modified building blocks

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Combine to create a biomaterial scaffold

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Add some bells and whistles

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Study the material in vitro

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Study the material in vivo

What we’re working on at the moment

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BRAIN HEROES

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SQUISHING INFLAMMATION

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SIMULATED MAP

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SYNTHETIC PLACENTA

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GENE DELIVERY

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STROKE ACROSS SEX

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HEALING CANCER

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SWEET BRAIN

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REPAIR SOUP

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FAT BIOMATERIALS