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Enzyme-responsive protein nanocapsules are synthesized to release their protein cargoes in response to specific enzymes secreted in certain cellular events not only with specificity but also with controlled rate by composition tuning. The unique nanocapsule structures protect the encapsulated proteins with robustness against reacting reaction system, providing a new direction towards responsive protein delivery according to specific cellular events or local environment.

Jing Wen, Sean M Anderson, Juanjuan Du, Ming Yan, Jun Wang, Meiqing Shen, Yunfeng Lu, Tatiana Segura

Wen, J; Anderson, SM; Du, J; Yan, M; Wang, J; Shen, M; Lu, Y; Segura, T