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Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

Suwei Zhu, Lina Nih, S Thomas Carmichael, Yunfeng Lu, Tatiana Segura

Zhu S, Nih L, Carmichael ST, Lu Y, Segura T