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An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.

Jie Li, Linlin Zhang, Yang Liu, Jing Wen, Di Wu, Duo Xu, Tatiana Segura, Jing Jin, Yunfeng Lu, Hui Wang

Li, J; Zhang, L; Liu, Y; Wen, J; Wu, D; Xu, D; Segura, T; Jin, J; Lu, Y; Wang, H